Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol NBR1 contributors: mct - updated : 17-05-2010
HGNC name neighbor of BRCA1 gene 1
HGNC id 6746
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
osteoarticularboneostťoporosis
identification of the detailed mechanism by which the NBR1 truncation leads to increased bone mass may be amenable to pharmacological manipulation to increase bone mass in osteoporotic patients
ANIMAL & CELL MODELS
  • truncation of the Nbr1 protein in mice results in an age-dependent increase in bone mass and BMD because of elevated osteoblast activity
  • T-cell-specific Nbr1-deficient mice show impaired lung inflammation and have defective Th2 differentiation