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FLASH GENE
Symbol LIPC contributors: mct - updated : 26-03-2020
HGNC name lipase, hepatic
HGNC id 6619
ASSOCIATED DISORDERS
corresponding disease(s) LIPCD , WHAR2
Susceptibility
  • to coronary heart disease, atherosclerosis, dyslipidemia(see LIPC)
  • to hyperalphalipoproteinemia
  • to advanced age-related macular degeneration (AMD)
  • to hypertension
  • to hypertensive disorders of pregnancy
  • Variant & Polymorphism other
  • haplotype in intron 1 associated to hyperalphalipoproteinemia
  • significant association between advanced AMD and the LIPC locus (Neale 2010)
  • expression level of LIPC was significantly associated with AMD pathology
  • associated with intermediate and large drusen and advanced age-related macular degeneration (
  • LIPC promoter variants rs493258 and rs10468017 were associated with advanced AMD
  • LIPC rs2070895 polymorphism was found to be related to an increased risk of hypertension
  • Variants -250G/A and -514C/T in the LIPC gene are associated with hypertensive disorders of pregnancy
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • hHLmt-expressing mice display severe hypoalphalipoproteinemia (