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FLASH GENE
Symbol MAPK3 contributors: mct/shn - updated : 06-10-2020
HGNC name mitogen-activated protein kinase 3
HGNC id 6877
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional somatic mutation      
Thr188 phosphorylation initiates hypertrophy in cardiomyocytes and is present in failing human hearts
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • p44 MAPK-deficient mice are viable, fertile, and of normal size but p44 MAPK-/- mice thymocyte maturation beyond the CD4+CD8+ stage was reduced by half and proliferation in response to activation with a monoclonal antibody to the T cell receptor in the presence of phorbol myristate acetate was severely reduced (
  • mice lacking ERK1 display a dramatic enhancement of striatum-dependent long-term memory (
  • disrupted Mapk1/mapk3 in mouse granulosa cells provide in vivo evidence that these kinases are necessary for LH-induced oocyte resumption of meiosis, ovulation, and luteinization
  • double knock-out newborn pups for Erk1 and Erk2 survived for not more one day, appeared normal just after parturition, displayed intracerebral hemorrhages with varying location and severity, ventricular zones and corpus callosum did not develop properly and nuclear morphology in some brain regions were markedly aberrant (
  • double knock-out mice deficient for Erk2 in the central nervous system, with ubiquitous homozygous deletion of Erk1 were neonatally lethal (