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HGNC UniGene Nucleotide OMIM UCSC
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FLASH GENE
Symbol CHRNA7 contributors: mct/npt/shn/pgu - updated : 23-01-2018
HGNC name cholinergic receptor, nicotinic, alpha 7 (neuronal)
HGNC id 1960
ASSOCIATED DISORDERS
corresponding disease(s) DEL15Q13 , DUP15Q13
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
may signal a compensatory response to maintain basocortical cholinergic activity during Alzheimer disease progression
tumoral     --over  
its expression is significantly higher in small-cell lung carcinoma (SCLC), as in carcinoid tumor
Susceptibility to autism spectrum disorder
Variant & Polymorphism other rare variants in autism spectrum disorder susceptibility
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
psychiatryschizophrenia 
repression of CHRNA7 mRNA by TFAP2A might be evaluated as a potential modulatory factor in the development of pharmacological targets to treat the symptoms of schizophrenia and other mood disorders
reproductiongenital 
activation of CHRNA7 might be a new candidate for treatment of endometriosis
neurologyneurodegenerativealzheimer
activation of the CHRNA7/PI3K signaling pathway and its cross-talk with the Wnt signaling pathway might well be therapeutic targets for potential AD treatments
ANIMAL & CELL MODELS
  • expression of CHRNA7 is significantly reduced frontal cortex from Rett syndrome and autism patients (
  • alpha7 nAChR knockout (KO) mouse is viable and has only slight visual dysfunction