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FLASH GENE
Symbol PRDX1 contributors: mct - updated : 03-11-2016
HGNC name peroxiredoxin 1
HGNC id 9352
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
is an important factor in esophageal squamous cancer progression and could serve as a useful prognostic marker
tumoral     --over  
in asbestos-related lung cancer-adenocarcinoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker potential use of PRDX1 as a biomarker for abdominal aortic aneurysm (AAA) evolution
Therapy target
SystemTypeDisorderPubmed
cancerreproductiveprostate
disrupting the interaction between PRDX1 and AR may serve as a fruitful new target in the management of prostate cancer
cancerreproductiveprostate
novel therapeutic target for prostate carcinoma
cancermetastases 
regulation of EMT induction by hPrx1 may be a potential target for therapeutic strategies directed against cancer metastasis
ANIMAL & CELL MODELS
  • Prdx1-deficient (Prdx1-/-) mice showed increased susceptibility to Mycobacterium tuberculosis