Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SS18 contributors: mct/npt - updated : 11-10-2021
HGNC name synovial sarcoma translocation, chromosome 18
HGNC id 11340
ASSOCIATED DISORDERS
corresponding disease(s) BSSX
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
fused with SSX1 or SSX2 in synovial sarcoma with translocation t(X;18)(p11.2-q11.2); see BSSX, SSX3, SSX4, SSX5
tumoral     --over  
of SS18-SSX1 enhanced TP53 ubiquitination and degradation in a manner dependent on the ubiquitin ligase activity of HDM2 (D'Arcy 2008)
tumoral fusion      
rearrangements of both USP6 and SS18, but histologic features were consistent with aneurysmal bone cyst throughout the lesion
tumoral fusion      
SS18-SSX2 fusion oncogene expression characterizes human synovial sarcomas
tumoral fusion      
SS18-NEDD4 gene fusion in primary renal synovial sarcoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancermuscle 
in synovial sarcoma, HDAC2 inactivation demonstrates significant therapeutic effect by degradation of the SS18-SSX driver oncoprotein
ANIMAL & CELL MODELS