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FLASH GENE
Symbol UTS2 contributors: mct - updated : 20-03-2013
HGNC name urotensin 2
HGNC id 12636
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in patients with heart failure and in patients with renal diseases
constitutional     --over  
of TAC3 and UTS2 in the plasma of pre-eclamptic women
Susceptibility
  • to NIDDM
  • to myocardial infarction in individuals with or without conventional coronary risk factors
  • Variant & Polymorphism other
  • S89N polymorphism is associated with the development of type 2 diabetes, via insulin sensitivity, in Japanese subjects
  • polymorphisms associated with myocardial infarction in individuals with or without conventional coronary risk factors
  • Candidate gene
    Marker
  • important marker of severity of portal hypertension in children
  • Therapy target
    SystemTypeDisorderPubmed
    miscelleaneousurinary 
    UTS2/UTS2R pathway may represent a novel therapeutical target in erectile dysfunction
    digestiveliver 
    potential therapeutic target in the chronic liver disease
    ANIMAL & CELL MODELS
  • 2DM mice showed increased Uts2/Uts2r content, in skeletal muscle