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FLASH GENE
Symbol GLI1 contributors: mct - updated : 21-10-2016
HGNC name GLI family zinc finger 1
HGNC id 4317
ASSOCIATED DISORDERS
corresponding disease(s) PAPA8
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
deregulating the SHH pathway and associated with basal cell carcinoma
tumoral fusion      
with ACTB in through the translocation t(7;12)(p22;q13), in pericytoma
tumoral somatic mutation amplification    
amplified in glioblastoma
tumoral     --over  
overexpression of MAP3K10 resulted in upregulation of GLI1 and GLI2 in pancreatic ductal adenocarcinoma (PDAC) cells
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerhemopathy 
development of GLI inhibitors, novel agents could be used to treat cancers including Ewing sarcoma family of tumors, which have activation of the pathway at the level of GLI
cancerreproductiveprostate
manipulating the SHH-GLI pathway, in combination with androgen ablation may prove to be useful for treatment of androgen-independent prostatic tumors
cancerreproductiveprostate
targeting the FERMT2-GLI1 feedback loop may facilitate the killing of prostate cancer cells
ANIMAL & CELL MODELS
  • inhibition of Shh signaling pathway exacerbated rat ischemic damage caused by permanent middle cerebral artery occlusion, which may be correlated with down-regulated expression of Gli1, Ptch1 and Sod1