Symbol
| GLI1
| contributors: mct - updated : 21-10-2016
|
HGNC name
| GLI family zinc finger 1
|
HGNC id
| 4317
|
corresponding disease(s)
|
PAPA8
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
| --over
|  
|
deregulating the SHH pathway and associated with basal cell carcinoma | tumoral
| fusion
|  
|  
|  
|
with ACTB in through the translocation t(7;12)(p22;q13), in pericytoma | tumoral
| somatic mutation
| amplification
|  
|  
|
amplified in glioblastoma | tumoral
|  
|  
| --over
|  
|
overexpression of MAP3K10 resulted in upregulation of GLI1 and GLI2 in pancreatic ductal adenocarcinoma (PDAC) cells | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
cancer | hemopathy | | |
development of GLI inhibitors, novel agents could be used to treat cancers including Ewing sarcoma family of tumors, which have activation of the pathway at the level of GLI | cancer | reproductive | prostate | |
manipulating the SHH-GLI pathway, in combination with androgen ablation may prove to be useful for treatment of androgen-independent prostatic tumors | cancer | reproductive | prostate | |
targeting the FERMT2-GLI1 feedback loop may facilitate the killing of prostate cancer cells |
| | | |
| inhibition of Shh signaling pathway exacerbated rat ischemic damage caused by permanent middle cerebral artery occlusion, which may be correlated with down-regulated expression of Gli1, Ptch1 and Sod1 |