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FLASH GENE
Symbol ITCH contributors: mct/pgu - updated : 12-09-2016
HGNC name itchy E3 ubiquitin protein ligase homolog (mouse)
HGNC id 13890
ASSOCIATED DISORDERS
corresponding disease(s) ITCHD
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in anaplastic thyroid carcinoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • absent in the non-agouti-lethal 18H or Itchy mice, which develop a severe immunological disease, including lung and stomach inflammation and hyperplasia of lymphoid and hematopoietic cells
  • Itch(-/-) mice develop an autoimmune disease phenotype characterized by itchy skin and multiorgan inflammation
  • adult Itch(-/-) mice had normal bone volume, but they had significantly increased LPS-induced osteoclastogenesis and bone resorption