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FLASH GENE
Symbol IL21 contributors: mct - updated : 10-04-2019
HGNC name interleukin 21
HGNC id 6005
ASSOCIATED DISORDERS
corresponding disease(s) CVID11
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --other  
IL21 and IL21R expression in lymphocytes and neurons in multiple sclerosis brain
tumoral     --low  
in osteosarcoma patients
Susceptibility to systemic lupus erythematosus (SLE)
Variant & Polymorphism SNP
  • both IL21 rs907715 and rs2221903 polymorphisms may be associated with SLE susceptibility
  • Candidate gene
    Marker
  • IL21 is a candidate biomarker of resistance to tuberculosis
  • Therapy target
    ANIMAL & CELL MODELS