Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
| --over
|  
|
prevented cardiac hypertrophy and fibrosis  | tumoral
|  
|  
| --over
|  
|
in several cancers, such as glioblastoma, colon, breast, prostate and lung cancers, often associated with drug resistance  | tumoral
|  
|  
| --low
|  
|
in specific tumors, such as ovarian, bladder and renal cancers, correlated with the worst prognoses and chemoresistance  | constitutional
| germinal mutation
|  
|  
|  
|
autoinflammatory disease might be enhanced by bi-allelic mutations  | |