Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

TRAP1

contributors: mct - updated : 26-01-2022

HGNC name	TNF receptor-associated protein 1
HGNC id	16264

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   prevented cardiac hypertrophy and fibrosis tumoral     --over   in several cancers, such as glioblastoma, colon, breast, prostate and lung cancers, often associated with drug resistance tumoral     --low   in specific tumors, such as ovarian, bladder and renal cancers, correlated with the worst prognoses and chemoresistance constitutional germinal mutation       autoinflammatory disease might be enhanced by bi-allelic mutations

Susceptibility

Variant & Polymorphism

Candidate gene	potential of TRAP1 inhibitors as neuroprotective drugs
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate targeting the TRAP1 pathway with Gamitrinibs could be explored as novel molecular therapy in patients with advanced prostate cancer cancer     targeting TRAP1 constitutes likely a new antitumor approach cancer endocrine thyroid TRAP1 inhibition may be regarded as potential strategy to target specific features of thyroid carcinoma (TC), cell proliferation and resistance to apoptosis

ANIMAL & CELL MODELS