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FLASH GENE
Symbol TRAP1 contributors: mct - updated : 26-01-2022
HGNC name TNF receptor-associated protein 1
HGNC id 16264
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
prevented cardiac hypertrophy and fibrosis
tumoral     --over  
in several cancers, such as glioblastoma, colon, breast, prostate and lung cancers, often associated with drug resistance
tumoral     --low  
in specific tumors, such as ovarian, bladder and renal cancers, correlated with the worst prognoses and chemoresistance
constitutional germinal mutation      
autoinflammatory disease might be enhanced by bi-allelic mutations
Susceptibility
Variant & Polymorphism
Candidate gene
  • potential of TRAP1 inhibitors as neuroprotective drugs
  • Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    targeting the TRAP1 pathway with Gamitrinibs could be explored as novel molecular therapy in patients with advanced prostate cancer
    cancer  
    targeting TRAP1 constitutes likely a new antitumor approach
    cancerendocrinethyroid
    TRAP1 inhibition may be regarded as potential strategy to target specific features of thyroid carcinoma (TC), cell proliferation and resistance to apoptosis
    ANIMAL & CELL MODELS