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FLASH GENE
Symbol TMPRSS3 contributors: mct - updated : 18-01-2012
HGNC name transmembrane protease, serine 3
HGNC id 11877
ASSOCIATED DISORDERS
corresponding disease(s) DFNB8 , DFNB10
related resource Hereditary Hearing Loss Homepage
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in breast and ovary tumors
constitutional   insertion    
beta satellite insertion
tumoral     --over  
in epithelial ovarian cancer
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerreproductiveovary
may represent an attractive target for immunotherapy of ovarian cancer
ANIMAL & CELL MODELS
  • Tmprss3Y260X homozygous mutation leads to syndromic autosomal recessive profound hearing loss in mice associated with a mild vestibular deficit