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FLASH GENE
Symbol CDKL3 contributors: mct/npt - updated : 20-12-2021
HGNC name cyclin-dependent kinase-like 3
HGNC id 15483
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       loss of function
in mental retardation
tumoral   deletion    
in dysmyelopoiesis
tumoral     --over  
in esophageal squamous cell carcinoma ESCC) with poor prognosis
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • biomarker for Osteosarcoma (OS) prognosis (
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbone 
    potential therapeutic target to treat AKT1 hyper-activated Osteosarcoma (OS)
    cancerdigestiveoesophagus
    may be as a new therapeutic target in ESCC
    cancerbrainglioma/neuroblstoma
    CDKL3 as a promising therapeutic target of glioma
    ANIMAL & CELL MODELS