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FLASH GENE
Symbol BIRC7 contributors: mct - updated : 02-04-2019
HGNC name baculoviral IAP repeat-containing 7
HGNC id 13702
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in a significant portion of non-small cell lung cancer
tumoral     --over  
in renal cell carcinoma
tumoral     --over  
protect tumor cells of neuroblastoma with amplified MYCN oncogene from genotoxic agents
tumoral     --over  
significantly higher in pancreatic ductal adenocarcinoma, than that in peritumoral tissue, benign pancreatic lesions, and normal pancreatic tissue
tumoral     --over  
is specifically over-expressed in adrenocortical carcinoma (ACC)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • BIRC7 upregulation might serve as a valuable biomarker of increased recurrence risk in advanced T stages and medium-grade prostate cancer
  • new molecular marker of adrenocortical carcinoma (ACC)
  • livin expression could be a novel prognostic marker in childhood ALL
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    therapeutic targeting of BIRC7 to block its antiapoptotic effect in neuroblastoma
    cancer  
    BIRC7 cleavage will become a highly potent proapoptotic agent, and a novel strategy for cancer therapy
    ANIMAL & CELL MODELS