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FLASH GENE
Symbol HDAC4 contributors: mct - updated : 02-02-2013
HGNC name histone deacetylase 4
HGNC id 14063
ASSOCIATED DISORDERS
corresponding disease(s) DEL2Q37 , BDMR
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
inhibited cardiomyogenesis, by the downregulation of cardiac muscle gene expression
tumoral     --low  
in colon carcinomas
constitutional     --low  
during normal retinal development led to apoptosis of rod photoreceptors and bipolar (BP) interneurons
constitutional     --over  
overexpression reduced naturally occurring cell death of the BP cells
tumoral     --low  
reduced in chondrosarcoma cells when compared with normal chondrocytes
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target useful target for new anti-cancer therapies based on selective inhibition of specific HDACs
ANIMAL & CELL MODELS
  • overexpression in a mouse model of retinal degeneration prolonged photoreceptor survival (in the mouse retina, HDAC4 has an essential role in neuronal survival)