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FLASH GENE

Symbol

HDAC4

contributors: mct - updated : 02-02-2013

HGNC name	histone deacetylase 4
HGNC id	14063

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DEL2Q37 , BDMR

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   inhibited cardiomyogenesis, by the downregulation of cardiac muscle gene expression tumoral     --low   in colon carcinomas constitutional     --low   during normal retinal development led to apoptosis of rod photoreceptors and bipolar (BP) interneurons constitutional     --over   overexpression reduced naturally occurring cell death of the BP cells tumoral     --low   reduced in chondrosarcoma cells when compared with normal chondrocytes

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	useful target for new anti-cancer therapies based on selective inhibition of specific HDACs

ANIMAL & CELL MODELS

overexpression in a mouse model of retinal degeneration prolonged photoreceptor survival (in the mouse retina, HDAC4 has an essential role in neuronal survival)