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FLASH GENE
Symbol ADNP contributors: mct - updated : 16-10-2015
HGNC name activity-dependent neuroprotector
HGNC id 15766
ASSOCIATED DISORDERS
corresponding disease(s) HVDAS
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
affects social interactions, a major hallmark of schizophrenia
constitutional     --over  
associated with the initial stages of the disease, possibly reflecting a compensatory effect
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Adnp haploinsufficiency in mice, results in age-related neuronal death, cognitive and social dysfunction, exhibited reduced hippocampal Becn1 and increased Bcl2 expression