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FLASH GENE
Symbol TIGAR contributors: mct/npt/pgu - updated : 03-12-2019
HGNC name chromosome 12 open reading frame 5
HGNC id 1185
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
ameliorated the effects of MET kinase inhibition, inhibiting tumor growth (
tumoral     --over  
in breast cancer (
tumoral     --over  
in colon tumors suggested that deregulated TIGAR supports cancer progression
tumoral     --over  
in glioblastomas
constitutional       loss of function
loss of TIGAR is a critical pathway mediating the effects of maternal obesity on oocyte quality
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • might be a predictor of poor survival and high incidence of relapse in AML patients
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    inhibition of a tyrosine kinase/TIGAR/NADPH cascade may have therapeutic applicability in human cancers
    cancerdigestivecolon
    potential therapeutic target in diseases such as intestinal cancer
    immunologyinflammatory 
    potential therapeutic target in diseases such as ulcerative colitis
    neurologyepilepsy 
    promising therapeutictarget for epilepsy
    cancerhemopathy 
    combination of TIGAR inhibitors with anti-glycolytic agents may be novel therapies for the future clinical use in AML (acute myeloid leukemia) patients
    cancer  
    could serve as a potential target for the development of effective antineoplastic therapies
    ANIMAL & CELL MODELS