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FLASH GENE
Symbol P2RY12 contributors: mct - updated : 23-01-2013
HGNC name purinergic receptor P2Y, G-protein coupled, 12
HGNC id 18124
ASSOCIATED DISORDERS
corresponding disease(s) P2RY12
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
might be detrimental to tissue integrity in cortical gray matter lesions in multiple sclerosis
constitutional       gain of function
in spinal microglia may be a critical event in the pathogenesis of neuropathic pain
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
bloodcoagulation 
potential target for the treatment of thromboembolisms and other clotting disorders
osteoarticularboneostéoporosis
P2RY12 inhibition is a potential therapeutic target for pathologic bone loss
miscelleaneouspain 
might be a viable therapeutic strategy for treating neuropathic pain
ANIMAL & CELL MODELS
  • mice lacking P2ry12 had decreased osteoclast activity and were partially protected from age-associated bone loss
  • blocking of P2ry12 in mice resulted in strongly reduced platelet aggregation in mice with elevated cholesterol levels compared with normocholesterolemic controls