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FLASH GENE
Symbol ADAMTS9 contributors: mct - updated : 24-01-2019
HGNC name ADAM metallopeptidase with thrombospondin type 1 motif, 9
HGNC id 13202
ASSOCIATED DISORDERS
corresponding disease(s) NPHP21
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral   deletion    
in hereditary renal tumors
tumoral        
in gastric cancer cell lines
tumoral        
by epigenetic disruption in colorectal cancer
Susceptibility to type 2 diabetes
Variant & Polymorphism other
  • ADAMTS9 genetic risk variants were associated with type 2 diabetes
  • ADAMTS9 rs4607103 C allele is one of the few gene variants proposed to increase the risk of type 2 diabetes through an impairment of insulin sensitivity
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 2 
    ADAMTS9 is a potential novel mode of treating insulin resistance.
    ANIMAL & CELL MODELS
  • mice lacking Adamts9 selectively in skeletal muscle have improved insulin sensitivity