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FLASH GENE
Symbol MAPK8IP3 contributors: mct/ - updated : 25-03-2019
HGNC name mitogen-activated protein kinase 8 interacting protein 3
HGNC id 6884
ASSOCIATED DISORDERS
corresponding disease(s) IDVBA
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
enhanced phosphorylation and kinase activation of JNK and reduced the inhibitory effect of cyclic MS (mechanical strain)
constitutional     --over  
in human hearts with hypertrophic cardiomyopathy (HCM)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cardiovascular  
blockage of MAPK8IP3 could alleviate cardiac hypertrophy via inactivating JNK pathway, and thus might be a promising strategy to prevent pathological cardiac hypertrophy
ANIMAL & CELL MODELS