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FLASH GENE
Symbol TMEFF2 contributors: mct - updated : 20-12-2011
HGNC name transmembrane protein with EGF-like and two follistatin-like domains 2
HGNC id 11867
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
by hypermethylation in sporadic colorectal and bladder cancer and in ulcerative colitis associated colorectal carcinoma
tumoral     --over  
in androgen-dependent prostate cancer
tumoral     --low  
in brain cancers and is negatively correlated with PDGFA expression
tumoral     --low  
silencing by methylation in esophageal squamous cell carcinoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • methylated SFRP2 and TMEFF2 detected in 94.2 p100, and 71.2 p100 of colorecal cancer (CRC), and methylation testing of fecal DNA may be a simple and promising non-invasive screening method for CRC and precancerous lesions
  • Therapy target immunotherapeutic target for the treatment of prostate cancer
    ANIMAL & CELL MODELS