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FLASH GENE
Symbol NR1H3 contributors: mct - updated : 23-08-2016
HGNC name nuclear receptor subfamily 1, group H, member 3
HGNC id 7966
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
Variant & Polymorphism SNP , other
  • a single nucleotide polymorphism, rs2279238, and a common haplotype, CAAGCC, were associated with obesity phenotypes
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascular  
    for intervention in cardiovascular disease
    osteoarticularboneothers
    clinical use of an LXR agonist would not only affect reverse cholesterol transport and inflammatory pathways but could significantly and negatively affect bone remodeling
    ANIMAL & CELL MODELS
  • Lxra -/- mice failed to induce transcription of the gene encoding cholesterol 7-alpha-hydroxylase. this defect was associated with a rapid accumulation of large amounts of cholesterol in the liver and the regulation of several other crucial lipid metabolizing genes was also altered(Peet, 98)
  • mice lacking Nr1h2, Nr1h3 manifested a breakdown in self-tolerance and developed autoantibodies and autoimmune glomerulonephritis