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FLASH GENE

Symbol

PIAS1

contributors: mct/ - updated : 08-03-2019

HGNC name	protein inhibitor of activated STAT, 1
HGNC id	2752

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     caused promoter demethylation, reduced histone H3 methylation at Lys9, and enhanced promoter accessibility

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	PIAS1 is a prognostic biomarker in breast cancer
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate PIAS1 is a promising target protein for a combined treatment approach to improve future PCa therapies

ANIMAL & CELL MODELS

	Pias1&
	8722;/&
	8722; mice displayed an increased natural Treg cell population and were resistant to the development of experimental autoimmune encephalomyelitis