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FLASH GENE
Symbol PIAS1 contributors: mct/ - updated : 08-03-2019
HGNC name protein inhibitor of activated STAT, 1
HGNC id 2752
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional   deletion    
caused promoter demethylation, reduced histone H3 methylation at Lys9, and enhanced promoter accessibility
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • PIAS1 is a prognostic biomarker in breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    PIAS1 is a promising target protein for a combined treatment approach to improve future PCa therapies
    ANIMAL & CELL MODELS
  • Pias1&
  • 8722;/&
    8722; mice displayed an increased natural Treg cell population and were resistant to the development of experimental autoimmune encephalomyelitis