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FLASH GENE
Symbol CRYAB contributors: mct/shn - updated : 02-10-2012
HGNC name crystallin, alpha B
HGNC id 2389
ASSOCIATED DISORDERS
corresponding disease(s) DRM , CPP2 , CMD1II , MMFIH
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
      --over  
in Alexander disease
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Cryab-/- mice showed worse experimental autoimmune encephalomyelitis at the acute and progressive phases, with higher Th1 and Th17 cytokine secretion from T cells and macrophages, and more intense central nervous system inflammation (
  • AxD mouse models that loss of Cryab results in increased mortality (