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FLASH GENE
Symbol DAB2IP contributors: mct/pgu - updated : 13-02-2010
HGNC name DAB2 interacting protein
HGNC id 17294
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --low  
in prostate cancer
tumoral fusion translocation    
fused with MLL in t(9;11) (q34;q23) in acute myeloid leukemia
tumoral        
leads to imbalance of cell survival and apoptosis pathways, which plays a significant role in tumor development
Susceptibility
  • to aggressive prostate cancer
  • to early onset myocardial infarction, peripheral arterial disease, abdominal aortic aneurysms and pulmonary embolism
  • Variant & Polymorphism SNP
  • in the DAB2IP gene is associated with risk of aggressive prostate cancer (PCa), and loss of DAB2IP expression is frequently detected in metastatic PCa
  • rs7025486[A] is associated with early onset myocardial infarction, peripheral arterial disease, abdominal aortic aneurysms and pulmonary embolism
  • Candidate gene
    Marker assessment of DAB2IP may provide a prognostic biomarker in prostate carcinoma metastasis
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    potential therapeutic target for Prostate Carcinoma metastasis
    ANIMAL & CELL MODELS
  • AIP1-deficient mice (AIP1-KO)
  • Dab2IP knock-down mice did not exhibit severe ataxia or cerebellar hypoplasia, but Dab2IP deficiency produced a number of cerebellar abnormalities such as a delay in the development of Purkinje cell (PC) dendrites