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FLASH GENE
Symbol KPNB1 contributors: mct/npt - updated : 28-12-2016
HGNC name karyopherin (importin) beta 1
HGNC id 6400
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in cervical cancer and are critical for cancer cell survival and proliferation (van der Watt 2009)
tumoral       gain of function
in hepatocellular carcinoma (HCC) tissue samples and increasing HCC cells growth and the KPNB1 expression was associated with poor survival
tumoral     --over  
in cervical cancer, critical for cervical cancer cell survival and proliferation
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • promising candidate as both biomarker in cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    therapeutic target for HCC
    cancer  
    potential anticancer therapeutic target
    cancerhemopathy 
    target for myeloma therapies
    cancerreproductiveuterus
    blocking KPNB1 has potential as an anticancer therapeutic approach
    ANIMAL & CELL MODELS