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FLASH GENE
Symbol AGR2 contributors: mct - updated : 11-01-2012
HGNC name anterior gradient 2 homolog (Xenopus laevis)
HGNC id 328
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in early stage mucinous ovarian tumors compared to normal ovarian tissues and serous type ovarian tumors
tumoral     --over  
in prostate cancer compared to non-malignant cells, but relatively lower levels of AGR2 are highly predictive of disease recurrence following radical prostatectomy
tumoral     --over  
in breast cancer
Susceptibility to ulcerative colitis
Variant & Polymorphism
Candidate gene
Marker
  • potential biomarker for the diagnosis of mucinous ovarian cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    utility of anti-AGR2 therapy in ER-positive breast cancers because of its impact on cancer-relevant pathways
    cancerdigestivepancreas
    may be a useful molecular target in pancreatic cancer
    ANIMAL & CELL MODELS
  • mice lacking Agr2 were viable but were highly susceptible to colitis, indicating a critical role for Agr2 in protection from disease