Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

AGR2

contributors: mct - updated : 11-01-2012

HGNC name	anterior gradient 2 homolog (Xenopus laevis)
HGNC id	328

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in early stage mucinous ovarian tumors compared to normal ovarian tissues and serous type ovarian tumors tumoral     --over   in prostate cancer compared to non-malignant cells, but relatively lower levels of AGR2 are highly predictive of disease recurrence following radical prostatectomy tumoral     --over   in breast cancer

Susceptibility

to ulcerative colitis

Variant & Polymorphism

Candidate gene
Marker	potential biomarker for the diagnosis of mucinous ovarian cancer
Therapy target
	System Type Disorder Pubmed cancer reproductive breast utility of anti-AGR2 therapy in ER-positive breast cancers because of its impact on cancer-relevant pathways cancer digestive pancreas may be a useful molecular target in pancreatic cancer

ANIMAL & CELL MODELS

mice lacking Agr2 were viable but were highly susceptible to colitis, indicating a critical role for Agr2 in protection from disease