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FLASH GENE
Symbol MKNK1 contributors: mct/npt - updated : 06-05-2015
HGNC name MAP kinase-interacting serine/threonine kinase 1
HGNC id 7110
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
induces the formation of multinucleated cells, which can be rescued by expressing a form of MNK1 that is resistant to RNA interference
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerhemopathy 
pharmacologic inhibition of the MKNK1, MKNK2 may be therapeutically useful blast crisis chronic myeloid leukemia
immunologyinflammatory 
in numerous chronic inflammatory disorders, MNK1 could represent an attractive therapeutic target
ANIMAL & CELL MODELS