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FLASH GENE

Symbol

ABCG5

contributors: mct - updated : 03-11-2015

HGNC name	ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1)
HGNC id	13886

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

STSL

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   increased ABCA1, ABCG5, and ABCG8 expression in cholesterol-related gallbladder diseases (CAGD)

Susceptibility

to myocardial infarction (MI) versus gallstone disease

Variant & Polymorphism other	genetic variation in ABCG5/8, which associates with decreased levels of plasma LDL cholesterol protects against MI, but increases the risk of symptomatic gallstone disease

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Abcg5/g8 deficiency in mice fed a chow diet markedly raises TG levels by impairing TG catabolism and by increasing liver and intestinal TG secretion
	overexpression of ABCG5 and ABCG8 in mice retards diet-induced atherosclerosis because of reduced circulating and hepatic cholesterol