Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CAPN10 contributors: mct - updated : 24-05-2014
HGNC name calpain 10
HGNC id 1477
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in glucose-tolerant but not glucose-intolerant individuals in response to prolonged exposure to fat
Susceptibility
  • to NIDDM1 (MIM601283) (rare in African people) with elevated free fatty acid levels, not major susceptibility gene
  • to polycystic ovary syndrome
  • to a worse prognosis in laryngeal cancer
  • Variant & Polymorphism SNP , other
  • complex relationship between polymorphism and disease, not proven to be causative
  • G/G variant of SNP-43 was associated with reduced insulin release in response to glucose in non-diabetic
  • (C) allele at SNP44 with increased risk of type 2 diabetes
  • UCSNP-63 genotype 12 seems to be related with a worse prognosis in laryngeal cancer
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS