SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,inner
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| intracellular,cytoplasm,organelle,mitochondria,interspace
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| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
text
| localized at mitochondria among enzymes of the de novo pyrimidine biosynthesis pathway |
basic FUNCTION
| catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis |
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catalyzes the only redox reaction in the pathway for pyrimidine biosynthesis |
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enzyme associated with the mitochondrial electron transport chain and required for de novo pyrimidine synthesis |
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flavin-dependent mitochondrial enzyme that catalyzes fourth reaction of pyrimidine de-novo synthesis |
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pyrimidine biosynthesis pathway is coupled to the mitochondrial RC (respiratory chain) via DHODH |
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mediates the fourth step of de novo pyrimidine biosynthesis and is a proven drug target for inducing immunosuppression in therapy of human disease as well as a rapidly emerging drug target for treatment of malaria |
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role of DHODH as a metabolic regulator of differentiation and point to its inhibition as a strategy for overcoming differentiation blockade in Acute Myeloid Leukemia |