basic FUNCTION
| may be involved in ubiquitin-dependent protein catabolism |
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plays an indispensible role in the NF-KB signaling pathway (negatively regulating NFKB1 activation) |
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acting as a negative regulator of TRAF2 and NF-kappa-B signaling pathway,and having receptor-dependent role of in regulating the IkappaB kinase pathway |
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playing a critical role in negatively regulating the c-Jun NH(2)-terminal kinase (JNK)and negatively regulates the activation of MKK7, an upstream kinase known to mediate JNK activation by immune stimuli |
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having a deubiquitinating activity that is directed towards non-Lys-48-linked polyubiquitin chains |
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acting as an ubiquitin thiolesterase |
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acting as a cysteine-type endopeptidase |
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regulates premitotic cell-cycle progression independent of NF-B pathway regulation, and CYLD function is required for efficient mitotic entry |
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having not only tumor-suppressing (apoptosis regulation) but also tumor-promoting activities (enhancer of mitotic entry); this additional function could provide an explanation for the benign nature of most cylindroma lesions |
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acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7 |
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enhancing tubulin polymerization into microtubules by lowering the critical concentration for microtubule assembly |
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having an inhibitory role in regulating type I IFN production during the RARRES3-mediated antiviral response |
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may represent a key regulatory factor in the necroptotic pathway |
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negatively regulates tubulointertitial inflammatory responses via suppressing activation of JNK in tubular epithelial cells, putatively attenuating the progressive tubulointerstitial lesions in IgA nephropathy |
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having role in immunity, lipid metabolism, spermatogenesis, osteoclastogenesis, antimicrobial defense, and inflammation |
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deubiquitinating enzyme that was shown to regulate cell proliferation, cell survival and inflammatory responses, mainly through inhibiting NF-kappaB signalling |
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controls cell growth and division at the G(1)/S-phase as well as cytokinesis by associating with alpha-tubulin and microtubules through its CAP-Gly domains |
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role in promoting inflammatory responses in VSMCs via a mechanism involving MAPK activation but independent of NFKB1 activity, contributing to the pathogenesis of vascular disease |
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in the liver, CYLD acts as an important regulator of hepatocyte homeostasis, protecting cells from spontaneous apoptosis by preventing uncontrolled MAP3K7 and JNK activation |
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essential role of CYLD in maintaining T cell homeostasis as well as normal T regulatory cell function, thereby controlling abnormal T cell responses |
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deubiquitinase specific for lysine63-linked polyubiquitins, highly enriched in the postsynaptic density fraction |
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acts as a key negative regulator to tightly control overactive inflammation |
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role of CYLD as a tumor suppressor in the pathogenesis of in chronic lymphocytic leukemia |
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inhibitor of NFKB-dependent immune responses |