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FLASH GENE
Symbol TAF1A contributors: mct - updated : 17-06-2020
HGNC name TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
HGNC id 11532
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Taf1a
Homologene
FAMILY
CATEGORY DNA associated , transcription factor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytoskeleton,microtubule
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • involved in the initiation of transcription by RNA polymerase 2
  • initiation of transcription for ribosomal RNA (rRNA) by RNA polymerase I requires TBP and TBP-associated factors (TAF1A, TAF1B and TAF1C)
  • TAF1A functions in recruitment of RNA polymerase I to ribosomal DNA promoters, the essential first step in ribosome biogenesis
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of SL1 (complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I), general transcription factor associated with POLR1, synthesis of 45S RNA precursors
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with helix 2 of TBP
  • TBP loading by AFF1 through TAF1A, TAF1B, TAF1C is the major rate-limiting step in MLL fusion-dependent transcription
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMDTAF1AD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS