protein
| activator of GATA4 gene expression during cardiac development and other GATA genes expression, bind to the N-terminal zinc finger of GATA4 and, via this interaction, repress GATA4-mediated transcriptional activation of various cardiac promoters |
|
corepressor of GATA5 through interaction with CTPB2 |
|
bind to GATA factors and function as transcriptional co-repressors in specific cell and promoter contexts |
|
intreacting with SERCA2 (SERCA2 is an important target and increased ZFPM2 expression may contribute to a decline in cardiac function in end-stage heart failure by impaired T3 signaling) (Rouf 2008) |
|
LHX9 gene represents the first direct target of the GATA4/ZFPM2 repressor complex in cardiac development |
|
cardiac expression of TNNT1 strictly depends on the physical interaction between GATA4-ZFPM2 in the myocardium of both atria and ventricles |
|
GATA4 may alter the activity of ZFPM2 by influencing its SUMOylation status |
|
sex determination requires interaction between the transcription factor GATA4 and its cofactor ZFPM2 |
|
ZFPM2 is a multi-zinc finger protein that binds the transcriptional activator GATA4 and modulates GATA4-mediated regulation of target genes during heart development |
|
ZFPM2/NuRD interaction is required for cardiomyocyte proliferation by directly down-regulating the cell cycle inhibitor CDKN1A during heart development |
|
novel function of hepatic ZFPM2 in insulin sensitivity and lipid metabolism through PPARA |