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FLASH GENE
Symbol PHLDA1 contributors: mct/shn - updated : 25-07-2012
HGNC name pleckstrin homology-like domain, family A, member 1
HGNC id 8933
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
proline histidine rich nuclear protein
HOMOLOGY
interspecies ortholog to Phlda1, Mus musculus
ortholog to Phlda1, Rattus norvegicus
ortholog to phlda1, Danio rerio
ortholog to PHLDA1, Pan troglodytes
intraspecies homolog to TSSC3
Homologene
FAMILY
CATEGORY regulatory , tumor suppressor
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic,vesicle
intracellular,nucleus
text
  • localized in the cytoplasm and the nucleoli
  • mainly expressed in the cytoplasm of neurons and glial cells
  • basic FUNCTION
  • involved in platelet cytoskeletal changes
  • may be playing an important role in the anti-apoptotic effects of insulin-like growth
  • plays a role in programmed cell death and tumorigenesis
  • shows an operon-like organization of two head-to-head oriented transcripts that are inversely regulated in T lymphocytes by a CpG-rich bidirectional promoter
  • possible role of this gene in the evolution of the pathology in intractable epilepsy
  • PHLDA1 upregulation strongly antagonizes Aurora-A-mediated oncogenic pathways
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HSF1
  • Aurora A
  • cell & other
    REGULATION
    Phosphorylated by AURKA
    Other regulated by estrogen via ER
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    is associated with estrogen receptor (ER) expression in breast carcinoma
    constitutional     --over  
    acts synergistically with AURKA inhibition in promoting cell death
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • putative epithelial stem cell marker in the human small and large intestine and contributes to migration and proliferation in colon cancer cells
  • Therapy target
    ANIMAL & CELL MODELS
  • downregulation of PHLDA1 is associated with estrogen receptor expression in breast carcinoma