Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DNMT3L contributors: SGE/npt - updated : 12-06-2009
HGNC name DNA (cytosine-5-)-methyltransferase 3-like
HGNC id 2980
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal cysteine-rich domain
  • a novel domain ADD (ATRX, DNMT3, DNMT3L) zinc finger containing a C2-C2 type of zinc finger
  • an imperfect PHD zinc finger with C4-C4
  • carboxy-terminal methyltransferase-like domain
  • HOMOLOGY
    Homologene
    FAMILY
  • zinc finger protein type C2-C2 family
  • C5 methyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • may be involved in gene expression or genome integrity
  • required for methylation of most imprinted loci in germ cells
  • required for the de novo methylation of imprinting control regions in female germ cells and for the de novo methylation of dispersed repeated sequences in male germ cells
  • stimulates de novo methylation by DNMT3A (Chedin 2002)
  • is thought to be required for the establishment of maternal genomic imprints
  • also mediates transcriptional repression through interaction with histone deacetylase 1
  • CELLULAR PROCESS nucleotide, genomic integrity
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with DNMT3B, via its catalytic domain
  • specifically interacts with the extreme amino terminus of histone H3 (recognizes histone H3 tails that are unmethylated at lysine 4 and induces DNA methylation by recruitment or activation of DNMT3A) (Ooi 2007)
  • interacting with the catalytic domain of DNMT3A (Jia 2007)
  • associates directly with both DNMT3A and -3B to potentiate methyltransferase activity (Novakovic 2010)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    loss of DNA methylation of the promoter in cancer cervix (Gokul 2007)
    constitutional     --over  
    by hypomethylation in full term and first trimester placental tissues (Novakovic 2010)
    Susceptibility
    Variant & Polymorphism other a rare change (R27Q) in amino acids is associated with significant DNA hypomethylation (El-Maari 2009)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS