Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UBAC1 contributors: mct - updated : 16-06-2021
HGNC name UBA domain containing 1
HGNC id 30221
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight CK2 phosphorylation sites
  • one helix-loop-helix (HLH) motif
  • a SRC homology (SH3) binding domain at the C terminus, P-X-X-P
  • HOMOLOGY
    Homologene
    FAMILY
  • ubiquitin family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • regulation of endothelial cell growth
  • expression of UBAC1 significantly impairs induction of TLR3 downstream target genes, acting on both NFKB1 and IRF3 signaling
  • UBAC1 affects viability and proliferation in primary keratinocytes
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component non-catalytic subunit of the E3 ubiquitin-protein ligase KPC complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • AIRE interacts with multiple components of the transcription complex including a novel interaction with the UBA domain protein, UBAC1
  • UBAC1 regulates HOXA2 by promoting its relocation to the cytoplasm
  • PPP1CB and UBAC1 together inhibit the activity of HOXA2 by activating its nuclear export, but favored HOXA2 de-ubiquitination and stabilization thereby establishing a store of HOXA2 in the cytoplasm
  • UBAC1 participates to TLR3 signaling in keratinocytes, affecting also cell viability and proliferation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS