basic FUNCTION
| may be involved in cell-surface proteolysis, cell adhesion or intracellular protein maturation |
|
involved in the restructuring of the mesangial matrix and in the migration of mesangial cells in disease |
|
adhesion receptor for platelet GPIIb-IIIa and induces platelet activation |
|
overexpressed in adenocarcinoma and highly associated with metastatic progression of prostate and breast cancers |
|
involved in cell migration and invasion |
|
could drive ITGA5 expression on cell surface via down-regulation of phosphorylated ERK1/2, novel mechanism by which ADAM15 regulates cell-matrix adhesion and migration |
|
contribute to the development of vascular inflammation |
|
having a novel function in regulating endothelial barrier properties |
|
is required for normal skeletal homeostasis and its absence causes increased nuclear translocation of CTNNB1 in osteoblasts leading to increased osteoblast proliferation and function, which results in higher trabecular and cortical bone mass |
|
primary role of ADAM15 for exosome-mediated tumor suppression, as well as functional significance of exosomal ADAM protein in antitumor immunity |
|
is involved in tumor progression and suppression |
|
dispensable for cutaneous wound healing and B16F1 melanoma growth, but significantly contributing to metastasis formation |
|
plays an unexpected role in TLR signaling, acting as an anti-inflammatory molecule through impairment of TICAM1-mediated TLR signaling |
|
is released into the extracellular space as an exosomal component, and ADAM15-rich exosomes have tumor suppressive functions |
|
pro-metastatic role of ADAM15 in lung cancer pogression, suggesting a novel mechanism of ADAM15 in promoting cancer cell invasion through directly targeting MMP9 activation |
|
catalytically active disintegrin membrane metalloproteinases that function as molecular signaling switches, shed membrane bound growth factors and/or cleave and inactivate cell adhesion molecules |
|
role of ADAM15 in the invasion of human bladder cancer |