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FLASH GENE
Symbol ST6GALNAC2 contributors: mlc - updated : 06-06-2006
HGNC name ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
HGNC id 10867
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
the L- and S- sialylmotifs
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
basic FUNCTION
  • catalyzing the synthesis of O-glycans
  • catalyzing the synthesis of O-glycans and the formation of mucin-related antigens in breast cancers
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer
    Susceptibility to IgA nephropathy
    Variant & Polymorphism other functional regulatory variant that may contribute to the genetic susceptibility in desialylation of IgA1 molecules causative pathogenesis of IgA nephropathy
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS