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FLASH GENE
Symbol PNCK contributors: npt - updated : 09-03-2006
HGNC name pregnancy up-regulated non-ubiquitously expressed CaM kinase
HGNC id 13415
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • serine/threonine protein kinase, whose catalytic and regulatory domains are highly similar to members of the CaM kinase family
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • CaMK subfamily
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • calcium/calmodulin dependent serine/threonine protein kinase, involved in the development of the central nervous system (hippocampus and dentrite gyrus)
  • may play a role in mammary development, and its expression may be restricted to a mammary epithelial cell type that is transformed in a subset of breast cancers
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in a subset of human primary breast cancers compared with benign mammary tissue
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target may represent an attractive therapeutic target in EGFR-regulated oncogenesis
    ANIMAL & CELL MODELS