motifs/domains
| a nucleotide-binding consensus site at the N terminus, and N-terminal region may regulate the availability of the unstructured loop for interactions with neighboring EHD2 dimers, thus promoting oligomerization |
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N-terminal P-loop and an ATPase domain |
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an EPS15 (EHD) protein binding domain, which facilitates canonical EHD protein interactions, was not required to direct overexpressed EHD2 to the cell surface |
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a bipartite nuclear localization signal |
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an unstructured loop consisting of two proline-phenylalanine (PF) motifs: KPFRKLNPF |
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a C-terminal EH domain; the EH domain is an EF hand-like structure that interacts with proteins containing an asparagine-proline-phenylalanine (NPF) motif |
basic FUNCTION
| participating in the clathrin-mediated endocytic machinery |
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also potentially involved in signal transduction pathways, downstream of receptor tyrosine kinases |
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playing a role in membrane reorganization in response to nucleotide hydrolysis |
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deforming liposomes into tubules |
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playing a role in membrane trafficking between the plasma membrane and endosomes |
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being important for the internalization of GLUT4 |
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required for normal fusion of myoblasts to skeletal muscle myotubes |
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regulate the exit of cargo from the recycling endosome |
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colocalize with vesicular and tubular structures, implying roles in transport processes and cytoskeletal dynamics and interact with specific phospholipids |
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required for normal translocation of FER1L5 to the plasma membrane |
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EHD proteins and ferlin proteins form discrete structures in myoblasts |
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regulates trafficking from the plasma membrane and recycling |
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has a role in nucleotide-dependent membrane remodelling and its ATP-binding domain is involved in dimerization, which creates a membrane-binding region |
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plasma-membrane-associated member of the EHD family that regulates internalization |
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EHD1 and EHD3 control traffic to the endocytic recycling compartment (ERC) and from the ERC to the plasma membrane, while EHD2 modulates internalization |