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FLASH GENE
Symbol NCKAP1 contributors: mct - updated : 18-11-2020
HGNC name NCK-associated protein 1
HGNC id 7666
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a large transmembrane segment
  • HOMOLOGY
    interspecies ortholog to rattus Nap1
    Homologene
    FAMILY
  • HEM-1/HEM-2 family (tyrosine kinase binding protein)
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • putative type II membrane protein
  • located at both nucleus and cytoplasm
  • basic FUNCTION
  • potentially involved in apoptosis of neuronal cells
  • NCKAP1 inhibit likely cells from entering G2/M phase
  • regulates neuronal cytoskeletal dynamics and is essential for neuronal differentiation in the developing brain
  • might have a cell-type-specific function in the development of neocortex
  • is likely essential for neuronal mechanical changes in the cytoskeleton, which are essential for accurate timing during post-migratory differentiation
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • protein constituent of membrane
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NCK associated
  • NCKAP1 is a cell invasion promoter by binding to WASF1, but also a tumor suppress gene that modulates the cell cycle of hepatocellular carcinoma (HCC) cell lines by targeting RB1/TP53 regulation
  • NCKAP1 interacts directly with CYFIP2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NDDAID
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in sporadic Alzheimer's disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    loss of Nckap1 in mice leads to neural tube and neuronal differentiation and migration defects in mouse developing brain