Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol TAX1BP3 contributors: shn/pgu - updated : 27-09-2012
HGNC name Tax1 (human T-cell leukemia virus type I) binding protein 3
HGNC id 30684
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single PDZ domain
  • S2P metal dependent membrane associated protease domain
    • HOMOLOGY
    interspecies ortholog to Tax1bp3, Mus musculus
    ortholog to tax1bp3, Danio rerio
    ortholog to TAX1BP3, Pan troglodytes
    Homologene
    FAMILY
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in Rho signaling to the serum response element
  • functioning as a negative regulator of PDZ-based scaffolding
  • may play a similar role in regulating the expression of other membrane proteins containing a type I PDZ ligand
  • may represent a novel regulatory element in the Wnt/beta-catenin signaling pathway
  • TAX1BP3 may act as an important regulator for the endocytic pathway of KCNJ4
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text important roles in cellular signaling, protein scaffolding and modulation of tumor growth (
    PATHWAY
    metabolism
    signaling
    a component Rho-rhotekin-TIP1
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Rho effector rhotekin (
  • Glutaminase L (
  • beta-catenin (
  • Kir 2.3 (
  • brain-specific angiogenesis inhibitor 2, BAI2
  • FAS, HTLV-1 Tax, HPV16 E6,
  • atypical PDZ-domain-containing protein, binding to KCNJ4 with a high affinity, causing the intracellular accumulation of KCNJ4 in cultured epithelial cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS