basic FUNCTION
| functioning as a repressor of E2F-dependent transcription during S phase |
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dominant-negative transcriptional repressor against other members of the E2F family (Kikuchi 2007) |
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provides a failsafe mechanism against loss of hematopoietic progenitor cells during proliferation (Kikuchi 2007) |
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playing a role in control of hypoxia-induced apoptosis through regulation of E2F1 (Yang 2008) |
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E2F6 serves to modulate E2F activity and protect cells including cardiomyocytes from apoptosis and improve survival |
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functions as a competing endogenous RNA, and transcriptional repressor, to promote ovarian cancer stemness |
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E2F-dependent transcription, through E2F6, determines the replication capacity of a cell, defined as the maximal amount of DNA a cell can synthesise per unit time during S-phase |
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E2F6 is required to initiate epigenetic silencing in early embryonic cells but becomes dispensable for the maintenance in differentiated cells |
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E2F6, a pocket protein-independent transcription repressor, is essential for hepatocellular carcinoma (HCC) cell growth, and its activities are controlled by USP22-mediated deubiquitination |