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FLASH GENE
Symbol INPP4A contributors: mct/npt - updated : 18-08-2007
HGNC name inositol polyphosphate-4-phosphatase, type I, 107kDa
HGNC id 6074
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • proline rich domain containing a PEST sequence
  • HOMOLOGY
    interspecies homolog to murine Inpp4a
    Homologene
    FAMILY
  • inositol-3,4-bisphosphate 4-phosphatase family
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • catalyze the hydrolysis of the D-4 position phosphoester of the PI3K generated lipid second messenger, phosphatidylinositol 3,4-bisphosphate (Shearn 2001)
  • generates and terminates phosphoinositide 3-kinase signals at distinct subcellular locations (Ivetac 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    phosphatidylinositol
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS