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FLASH GENE
Symbol SLC25A12 contributors: mct - updated : 11-09-2019
HGNC name solute carrier family 25 (mitochondrial carrier, Aralar), member 12
HGNC id 10982
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal domain containing four calcium binding EF-hands
  • six putative transmembrane domains
  • a C terminal with three tandemly repeated the mitochondrial carrier protein domain superfamily
  • HOMOLOGY
    Homologene
    FAMILY solute carrier family 25,mitochondrial
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,interspace
    text integral membrane protein,N terminal region in the interspace C terminus in the inner membrane
    basic FUNCTION
  • mitochondrial carrier aralar,isoform of the calcium-binding aspartate/glutamate exchanger
  • calcium-regulation of mitochondrial respiration maintains ATP homeostasis and requires SLC25A12-Malate Aspartate Shuttle in intact cortical neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    text
  • calcium dependent mitochondrial soluble carrier
  • energy transfer
  • PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein substrate for the TIMM8A/TIMM13 complex
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AUTS5 , EIEE39
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS