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FLASH GENE
Symbol POLM contributors: - updated : 26-05-2006
HGNC name polymerase (DNA directed), mu
HGNC id 9185
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
BRCT domain,an helix-loop-helix (HLH) DNA-binding motif and a POLX domain
HOMOLOGY
interspecies homolog to murine Polm (DNA polymerase mu);
intraspecies homolog to NTT (deoxynucleotilyltransferase)
Homologene
FAMILY POLX family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • putative mutator polymerase involved in somatic hypermutation of Ig genes
  • involved in the non homologous end-joining pathway for repair of double-strand breaks
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component forming a stable complex with XRCC4-ligase 4 and recruiting it to Ku (G22P1 - XRCC5 - PRKOC) to the DNA ends
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS