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FLASH GENE
Symbol ZNF281 contributors: mct - updated : 14-11-2017
HGNC name zinc finger protein 281
HGNC id 13075
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four Krüppel type zinc finger motifs
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • regulating ornithine decarboxylase gene expression
  • regulating gastrin gene expression
  • involved in transcriptional regulation
  • mediates NANOG autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming
  • epithelial-mesenchymal transition (EMT)-inducing transcription factor (EMT-TF)
  • zinc-finger factor involved in the control of cellular stemness and epithelial-mesenchymal transition (EMT)
  • is a key transcriptional regulator for primed pluripotency that also functions as a barrier toward achieving naive pluripotency in ESCs
  • involved in embryonic stem cell differentiation and tissue development
  • role of ZNF281 in pancreatic cancer progression
  • acts at a nexus of cardiac and inflammatory gene programs, which exert opposing influences on fibroblast to cardiac reprogramming
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the GC rich promoter element of gastrin and ODC
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • directly activate NANOG expression by binding to a site in the promoter in very close proximity to the POU5F1 and SOX2 binding sites
  • is required for NANOG binding to its own promoter, suggesting that NANOG-associated repressive complex(es) involving ZNF281 may fine-tune NANOG expression for pluripotency of ESCs
  • ZNF281 plays an important role in the maintenance and osteogenic differentiation of stem cells via the transcriptional regulation of genes including CTNNB1
  • NANOG is subjected to a negative autoregulatory mechanism, i.e., autorepression, in ESCs, and such autorepression requires the coordinated action of the NANOG partner and transcriptional repressor ZNF281
  • as ZNF281 physically interacts with the transcription factors NANOG, OCT4, SOX2, and MYC, it has been implicated in the regulation of pluripotency, stemness, and cancer
  • involvement of ZNF281 in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms
  • ZFP281 interacts with TET1, but not TET2
  • ZFP281 is a critical factor generally associating with AFF3 at enhancers and functioning together with AFF3 in regulating the expression of a subset of genes
  • promotes pancreatic cancer cells proliferation and invasion by interacting and up-regulating CTNNB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS