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FLASH GENE
Symbol ADAM11 contributors: mct/np - updated : 07-11-2007
HGNC name ADAM metallopeptidase domain 11
HGNC id 189
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • domains similar to hemorrhagic snake venom proteins (HSVP) with a prodomain
  • a disrupted Zn-binding site metalloproteinase
  • a disintegrin-like domain
  • a cysteine-rich domain
  • an EGF-like repeat
  • a transmembrane (TM) domain and a cytoplasmic tail
  • conjugated GlycoP , MetalloP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • ADAM (a disintegrin and metalloprotease domain) family
  • CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane-anchored proteins structurally related to snake venom disintegrins
    basic FUNCTION
  • a disintegrin and metalloprotease (inactive), cell surface adhesion protein implicated in cell-cell and cell-matrix interactions
  • has only a minor effect on cell growth
  • CELLULAR PROCESS protein, post translation
    protein, degradation
    PHYSIOLOGICAL PROCESS development
    text neurogenesis muscle development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • integrins
  • with ADAM22 and ADAM23, binds LGI1 and LGI4 (LGI-ADAM system seems to be regulated not only by the affinity but also by the cell-type-specific expression of each protein) (Sagane 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in low- and high-grade gliomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS