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FLASH GENE
Symbol ADAM29 contributors: mct - updated : 10-04-2012
HGNC name ADAM metallopeptidase domain 29
HGNC id 207
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • domains similar to hemorrhagic snake venom proteins (HSVP)
  • a Zn-binding site metalloproteinase
  • a disintegrin-like domain
  • a cysteine rich domain
  • an EGF-like repeat
  • a transmembrane domain and a cytoplasmic tail
  • conjugated GlycoP , MetalloP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • ADAM (a disintegrin and metalloprotease domain) family
  • CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • a disintegrin and metalloprotease (likely non catalytic), cell surface adhesion protein involved in spermatogenesis
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    often mutated in melanoma, and could play a role in melanoma progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia
  • Therapy target
    ANIMAL & CELL MODELS